Bio 365S Homework 3 A. CO Poisoning and 2o Drowning Last summer, a 15 year old named Sarah disappeared while boating with friends on Lake Travis
Bio 365S Homework 3
A. CO Poisoning and 2o Drowning Last summer, a 15 year old named Sarah disappeared while boating with
friends on Lake Travis. She was last seen alive holding on to the back end of an idling boat. When found, her
blood contained elevated levels of carbon monoxide (CO), and her lungs were filled with interstitial fluid, a
condition known as secondary drowning
1. How can exposure to fumes from a motor cause CO poisoning? (you may need to do online research) (2 pts) 2. Which is NOT a symptom of CO poisoning? Circle all that are not symptoms. Do research, if necessary!
(1/2 pt each,3 pts)
f. cherry-red blood
3. Briefly explain your answer to “Which is NOT a symptom…” (2 pts) 4. How can a small increase in CO in the atmosphere have such a potentially deadly effect? Use bullet points to
explain. (6 pts) 5. a. List 2 ways CO poisoning is SIMILAR to anemia. (4 pts) b. List 2 ways CO poisoning DIFFERS from anemia. 6. This figure is similar to the dissociation curve, and shows blood oxygen content curves under 3 conditions:
normal conditions, with CO poisoning (HbCO; carboxyhemoglobin) and in anemia.
a. Based on the graph, how does amount of oxygen bound at lungs
compare between HbCO and reduced Hb (anemia)? Write >, <, or =
in blank. (4 pts)
b. At a PO2 = 40 mm Hg, is it preferable to be anemic or have
sublethal carbon monoxide poisoning? Circle one:
Explain, based on the graph. (2 pts) 7. a. Use the HbO2 data posted online to fill in the blanks in order to determine O 2 content of blood for a
normal person versus an anemic. (6 pts)
Dissolved O2 content (mL/dL)
O2 bound to Hb (mL/dL)
Total O2 content (mL/dL) Normal
100 mm Hg (torr)
15 g/dL Anemic
100 mm Hg
10 g/dL b. Based on the normal data above, if an individual has 50% carboxyhemoglobin, what is his total oxygen
content in mL/dL blood? (2 pts)
8. Draw a graph on the axes to show how Hb content affects % saturation. Hint: use one of the data sets posted
(6 pts) 9. Secondary drowning can occur when water is aspirated. This water irritates lung tissue causing water to
exude into the alveoli from the interstitial fluid. Alveolar edema is the hallmark of
which is a
disorder. This condition decreases
, by overwhelming
in the lungs. What happens to lung volumes as a result?
What other major aspect of “successful respiration” is directly impacted, and how? (8 pts) B. Compare/Contrast Other Respiratory pathologies Match the disorder to the description by
placing the correct letter in the blank. Each blank may have more than one answer; each letter may be
used multiple times. Write none if none fit. A = Asthma
P = pneumothorax F = fibrosis
NRDS E= Emphysema
Plasma PO2 & PCO2 are normal TPP = zero mm Hg IPP often > IB pressure best treated with muscarinic agonist High inspiratory capacity low FEV1/%FVC Obstructive disorder low surfactant High elastic recoil hemoglobin reduced C. The Ice Man Wim Hof is a 57 year old, 180 lb Dutch man who is nicknamed “The Ice Man” due to his
ability to endure extreme cold. Wim Hof can also endure extreme heat and dryness, and he can hold his breath
for over six minutes. One of Wim Hof’s most notorious feats is climbing to 22,000 ft on Everest (short of the
peak) without supplemental oxygen, wearing only shorts and shoes.
1. Do some research, and find the Patm at 22,000 ft.
mm Hg What is the partial pressure of oxygen
at this atmospheric pressure?
Estimate his alveolar & plasma PO2 while at 22,000 ft. Alveolar
Estimate his % saturation at this PO2.
2. What is the total blood oxygen of a mountain climber whose hemoglobin is 16 g/dL but arterial P O2 is 20 mm
Hg? Note that hemoglobin binds 1.34 ml O2 per g Hb when Hb is 100% saturated, and that he has 5 L blood.
You will also need the posted HbO2 data to help you answer. (5 pts) 3. While most climbers have to spend a week or so at base camp before ascending, Wim Hof does not.
However, he has basically spent most of his adult life in preparation for such extreme climates by repeatedly
submerging himself in ice and by exposing himself to hypobaric conditions. His preparations have been
effective because hypoxia . . . circle all correct!
a. causes more oxygen to be released to the tissues
d. upregulates production of myoglobin
b. stimulates increased EPO production and thus increased Hb e. increases dissolved O2 in blood
c. causes increased hematocrit via increased plasma production
4. What is the effect of cold upon oxygen released to tissues? Circle one: increase
Briefly explain. (4 pts) decrease no change Note: According to actual data collected, Wim Hof can maintain normal core temperature and heart rate,
despite a surface body temperature of 4 oC! He does this by “controlling his autonomic nervous system.”
5. One of Wim Hof’s techniques is to practice breath control. For starters, he forcibly hyperventilates, such that
his breathing rate increases from 15 to 30 breaths per minute, and his tidal volume increases from 900 to 3 L.
a. What is his normal resting alveolar ventilation rate? Show work. Answer: b. His alveolar ventilation when hyperventilating is
ventilation. times greater than his normal alv
(2 pts) 6. When Wim Hof forcibly hyperventilates, what is the: (6 pts)
Effector(s) specific for expiration: